Biomedizinische Physik

Lehrveranstaltungen mit Beteiligung der Arbeitsgruppe

Ausgeschriebene Angebote für Abschlussarbeiten an der Arbeitsgruppe

Evaluierung der Variation des Röntgen-Dunkelfeld-Signals in einer vorklinischen Studie an Ex-Vivo Lungenproben

X-ray darkfield imaging has evolved as a novel x-ray imaging method, and offers great potential in the detection and visualisation of lung diseases (e.g. emohysema, fibrosis, lung cancer). In this project the variation of the darkfield signal variation shall be investigated in a small study with preclinical ex-vivo lung specimens. The work will be carried out in close collaboration with the Institute for Radiology and the Klinikum rechts der Isar.

geeignet als

• Masterarbeit Physik der kondensierten Materie
• Masterarbeit Kern-, Teilchen- und Astrophysik
• Masterarbeit Biophysik
• Masterarbeit Applied and Engineering Physics

Themensteller(in): Franz Pfeiffer

Fabrication of Grating-Structures for X-Ray Phase-Contrast Imaging using microstructured Si-Templates

X-ray phase-contrast radiography and computed tomography is a recently developed novel biomedical imaging method that allows for a better contrast in soft tissues. It has the potential to improve diagnosis of lung diseases and detection of tumor metastasis and is currently implemented in first clinical prototype systems. Presently, the required grating structures are made from Gold, which is too costly for large-area applications in the clinics. This master thesis focuses on the exploration of alternative materials to replace Gold as filling material.

geeignet als

• Masterarbeit Physik der kondensierten Materie
• Masterarbeit Kern-, Teilchen- und Astrophysik
• Masterarbeit Biophysik
• Masterarbeit Applied and Engineering Physics

Themensteller(in): Franz Pfeiffer

Spectral computed tomography for multi-material decomposition

Spectral computed tomography (CT) is an advancement of conventional CT. By using energy-resolving photon counting detectors, the technique offers several advantages compared to conventional CT. Besides a strong reduction in image noise and with that reduction of radiation dose, spectral CT enables an accurate determination of the chemical composition of an object. In the clinical routine this can be used to quantify the concentration of contrast agents in different organs in the human body. Making use of the K-edge discontinuities of different chemical elements allows for a clear separation between e.g. calcareous deposits and clinical contrast agents. However, spectral CT is not yet used for clinical diagnosis because the development of photon counting detectors with multiple energy bins which fulfill the clinical requirements is difficult.  The aim of the thesis is to evaluate the possibilities of multi-material decomposition with a novel prototype of a multi-bin photon-counting detector and to study the adaptability to different clinical cases. Furthermore new materials, such as gadolinium and tantalum, should be analyzed with respect to their potential usage as clinical contrast agents. The thesis  will be split between experimental activity in the laboratory (60 %) and data analysis, algorithmic implementation and computer simulations (40%).

 

geeignet als

• Masterarbeit Physik der kondensierten Materie
• Masterarbeit Kern-, Teilchen- und Astrophysik
• Masterarbeit Biophysik
• Masterarbeit Applied and Engineering Physics

Themensteller(in): Franz Pfeiffer

Abgeschlossene und laufende Abschlussarbeiten an der Arbeitsgruppe