Biomedizinische Physik

Prof. Franz Pfeiffer

Forschungsgebiet

Our interdisciplinary research portfolio is focused on the translation of modern x-ray physics concepts to biomedical sciences and clinical applications. We are particularly interested in advancing conceptually new approaches for biomedical x-ray imaging and therapy, and work on new kinds of x-ray sources, contrast modalities, and images processing algorithms. Our activities range from fundamental research using state-of-the-art, large-scale x-ray synchrotron and laser facilities to applied research and technology transfer projects aiming at the creation of improved biomedical device technology for clinical use. From a medical perspective, our work currently targets early cancer and osteoporosis diagnostics.

Adresse/Kontakt

James-Franck-Str. 1
85748 Garching b. München
+49 89 289 12552
Fax: +49 89 289 12548

Mitarbeiterinnen und Mitarbeiter der Arbeitsgruppe

Professorinnen und Professoren

Mitarbeiterinnen und Mitarbeiter

Lehrangebot der Arbeitsgruppe

Lehrveranstaltungen mit Beteiligung der Arbeitsgruppe

Titel und Modulzuordnung
ArtSWSDozent(en)Termine
Vertiefung Experimentalphysik 2 (LB-Technik)
Zuordnung zu Modulen:
VU 4 Herzen, J. Freitag, 09:00–13:00
sowie Termine in Gruppen

Ausgeschriebene Angebote für Abschlussarbeiten an der Arbeitsgruppe

Fabrication of Grating-Structures for X-Ray Phase-Contrast Imaging using X-Ray Lithography

X-ray phase-contrast radiography and computed tomography is a recently developed novel biomedical imaging method that allows for a better contrast in soft tissues. It has the potential to improve diagnosis of lung diseases and detection of tumor metastasis and is currently implemented in first clinical prototype systems. This master thesis focuses on the further development and characterisation of grating structures using x-ray lithography from the ANKA synchrotron in Karlsruhe.

The thesis will be carried out in collaboration with the Karlsruhe Institute of Technology and the candidate will spent most if his time in Karlsruhe.

geeignet als
  • Masterarbeit Physik der kondensierten Materie
  • Masterarbeit Kern-, Teilchen- und Astrophysik
  • Masterarbeit Biophysik
  • Masterarbeit Applied and Engineering Physics
Themensteller(in): Franz Pfeiffer
Machine Learning for Biomedical Imaging Applications Clinical CT and Radiography

This project explores the application of state-of-the-art machine learning algorithms for automized detection of diseases in radiology. It will specifically adress the early detection of stroke in computed tomography and tuberculosis in chest radiography.

This project will be carried out at the Chair for Computer Vision and Pattern Recognition (Prof. Cremers) at TUM Informatics, and in collaboration with the Institute for Radiology at the Klinikum rechts der Isar (PD Dr. Muenzel).

 

geeignet als
  • Masterarbeit Physik der kondensierten Materie
  • Masterarbeit Kern-, Teilchen- und Astrophysik
  • Masterarbeit Biophysik
  • Masterarbeit Applied and Engineering Physics
Themensteller(in): Franz Pfeiffer
Monte Carlo-based scatter correction for spectral computed tomography

In spectral x-ray computed tomography (spectral CT), tomographic scans of an object are conducted with two or more different photon energy spectra. This can be realized with photon counting detectors, which are able to partially resolve the energy of the detected photons. And contrary to conventional CT, spectral CT allows to retrieve information about the energy-dependent x-ray attenuation of the sample. The goal of this thesis is to develop a Monte Carlo-based scattering simulation framework for spectral CT and validate it with experimental measurements. Finally, the simulation framework should be combined with an existing iterative reconstruction algorithm in order to improve the quantitative accuracy of spectral CT and eliminate image artifacts. Experience with one (or more) of the following programming languages is desirable:  Python, C/C++, OpenCL.

geeignet als
  • Masterarbeit Physik der kondensierten Materie
  • Masterarbeit Kern-, Teilchen- und Astrophysik
  • Masterarbeit Biophysik
  • Masterarbeit Applied and Engineering Physics
Themensteller(in): Franz Pfeiffer
Quantitative Phase-Contrast-Based Iodine Imaging

Simultaneous access to phase- and absorption-contrast in X-ray computed tomography is provided by a Talbot-Lau interferometer at a laboratory setup. The complementary information of these two signals can be used for material decomposition and improved image processing. The project is focussed to clinical applications, especially separation of iodine and blood in an interventional stroke setting. The proposed thesis includes sample preparation, development of appropriate phantoms and independent accomplishement of the measurements on the experimental side. Development of the decomposition code based on theoretical models is a further step of the master project. 

geeignet als
  • Masterarbeit Physik der kondensierten Materie
  • Masterarbeit Kern-, Teilchen- und Astrophysik
  • Masterarbeit Biophysik
  • Masterarbeit Applied and Engineering Physics
Themensteller(in): Franz Pfeiffer

Abgeschlossene und laufende Abschlussarbeiten an der Arbeitsgruppe

Advanced Algorithms for reconstruction of phase-contrast computed tomography
Abschlussarbeit im Masterstudiengang Physik (Physik der kondensierten Materie)
Themensteller(in): Franz Pfeiffer
Psychophysical study of pitch perception in cochlear-implant users
Abschlussarbeit im Masterstudiengang Physik (Biophysik)
Themensteller(in): Franz Pfeiffer
Quantitative Phase-Contrast-Based Iodine Imaging
Abschlussarbeit im Masterstudiengang Physics (Applied and Engineering Physics)
Themensteller(in): Franz Pfeiffer
X-Ray dark-field imaging for material science applications
Abschlussarbeit im Masterstudiengang Physics (Applied and Engineering Physics)
Themensteller(in): Franz Pfeiffer
X-Ray dark-field imaging for material science applications
Abschlussarbeit im Masterstudiengang Physics (Applied and Engineering Physics)
Themensteller(in): Franz Pfeiffer
Synchrotron-based high-resolution micro-CT investigation of staining methods for tissue samples
Abschlussarbeit im Masterstudiengang Physik (Biophysik)
Themensteller(in): Franz Pfeiffer
Investigating the origin of the alveolar X-ray dark-field signal and quantification of pulmonary X-ray dark-field imaging
Abschlussarbeit im Masterstudiengang Physik (Biophysik)
Themensteller(in): Franz Pfeiffer

Biophysik

Biologische Systeme, vom Protein bis hin zu lebenden Zellen und deren Verbänden, gehorchen physikalischen Prinzipien. Unser Forschungsbereich Biophysik ist deutschlandweit einer der größten Zusammenschlüsse in diesem Bereich.