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M.Sc. Thorsten Sellerer

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Biomedizinische Physik

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Spectral computed tomography for multi-material decomposition

Spectral computed tomography (CT) is an advancement of conventional CT. By using energy-resolving photon counting detectors, the technique offers several advantages compared to conventional CT. Besides a strong reduction in image noise and with that reduction of radiation dose, spectral CT enables an accurate determination of the chemical composition of an object. In the clinical routine this can be used to quantify the concentration of contrast agents in different organs in the human body. Making use of the K-edge discontinuities of different chemical elements allows for a clear separation between e.g. calcareous deposits and clinical contrast agents. However, spectral CT is not yet used for clinical diagnosis because the development of photon counting detectors with multiple energy bins which fulfill the clinical requirements is difficult.  The aim of the thesis is to evaluate the possibilities of multi-material decomposition with a novel prototype of a multi-bin photon-counting detector and to study the adaptability to different clinical cases. Furthermore new materials, such as gadolinium and tantalum, should be analyzed with respect to their potential usage as clinical contrast agents. The thesis  will be split between experimental activity in the laboratory (60 %) and data analysis, algorithmic implementation and computer simulations (40%).

geeignet als
  • Masterarbeit Physik der kondensierten Materie
  • Masterarbeit Kern-, Teilchen- und Astrophysik
  • Masterarbeit Biophysik
  • Masterarbeit Applied and Engineering Physics
Themensteller(in): Franz Pfeiffer
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