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Theory of Complex Bio-Systems

Prof. Ulrich Gerland

Research Field

In physics, interactions between particles follow laws. In biology, interactions between biomolecules serve a function. We study the physics of biological functions. In particular, we are interested in cases where the implementations of biological functions are constrained by physical principles. Methods from statistical physics help to describe the functioning of complex biomolecular systems on a coarse-grained, but quantitative level.

Address/Contact

James-Franck-Str. 1/I
85748 Garching b. München

Members of the Research Group

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Office

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Teaching

Course with Participations of Group Members

Offers for Theses in the Group

Interplay of mechanics and information processing in cell tissues

A common theme in developmental biology and useful feature for synthetic systems is the coupling of patterning processes (cell differentiation) with mechanical processes and cell growth and death. Understanding the interplay of these different processes is crucial to be able to explain development, as well as to manipulate pattern formation processes in  synthetic systems. In this thesis, a well-known model of tissue dynamics will be implemented and coupled to intercellular signaling dynamics in order to answer questions about the stability and robustness of the pattern creation process and the role of initial and boundary conditions. Of particular interest will be the study of feedbacks between the ‘mechanics’ and the ‘information processing’ in these systems.

suitable as
  • Master’s Thesis Biophysics
  • Master’s Thesis Applied and Engineering Physics
  • Master’s Thesis Theoretical and Mathematical Physics
Supervisor: Ulrich Gerland

Current and Finished Theses in the Group

Effects of histone depletion and remodeler knockout on nucleosome positioning in S. cerevisiae
Abschlussarbeit im Masterstudiengang Physik (Biophysik)
Themensteller(in): Ulrich Gerland
Impact of Complex Spikes on the Integration of Parallel Fiber Input in Purkinje Cells
Abschlussarbeit im Masterstudiengang Physik (Biophysik)
Themensteller(in): Ulrich Gerland
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