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M.Sc. Stephan Kremser

Phone
+49 89 289-12388
Room
PH: 3325
E-Mail
stephan.kremser@tum.de
Links
Homepage
Page in TUMonline
Group
Theory of Complex Bio-Systems

Courses and Dates

Title and Module Assignment
ArtSWSLecturer(s)Dates
Exercise to Advanced Statistical Physics
Assigned to modules:
UE 2 Göppel, T. Gough, Z. Kremser, S.
Responsible/Coordination: Gerland, U.
dates in groups

Offered Bachelor’s or Master’s Theses Topics

Pattern Formation via Local Cell-Cell Signaling with Variable Interaction Ranges

Pattern formation phenomena occur in many different contexts ranging from physical and chemical systems to developmental biology and synthetic biology. In developmental biology, the correct relative positioning and determination of different cell fates is essential to ensure that the organism functions correctly. Whilst many models for pattern formation exist, the focus here is on cellularized systems with interactions only between nearby cells. This form of communication has previously received less attention from theoretical research than e.g. long-range diffusible signals as a means of communication. Our goal is to explore fundamental limits, patterning concepts, and engineering potential with a simple top-down model. Building on previous work, the project will concentrate on searching mechanisms of pattern formation with the goal of investigating how the interaction range can influence the ability to realiably create paradigmic patterns like striped "French Flag" patterns with tunable widths of the stripes. Prior knowledge in biology/biophysics is not needed, but interest in theoretical physics and computational problem solving is expected.

suitable as
  • Bachelor’s Thesis Physics
Supervisor: Ulrich Gerland
Two-dimensional Pattern Formation via Local Cell-Cell Signaling
Pattern formation phenomena occur in many different contexts ranging from physical and chemical systems to developmental biology and synthetic biology. For instance, in developmental biology, the correct relative positioning and determination of different cell fates is essential to ensure that the organism functions correctly. Whilst many models for pattern formation have been studied, the focus here is on cellular systems with interactions only between neighboring cells. This form of communication has previously received less attention from theoretical research than e.g. long-range diffusible signals as a means of communication. Our goal is to explore fundamental limits, patterning concepts, and engineering potential with a simple top-down model. Building on previous work, the project will concentrate on searching mechanisms of pattern formation with the goal of investigating which information processing and communication logics can robustly produce different prototypical patterns in two spatial dimensions. Prior knowledge in biology/biophysics is not needed, but interest in theoretical physics and computational problem solving is expected.
suitable as
  • Master’s Thesis Applied and Engineering Physics
Supervisor: Ulrich Gerland

Publications

Programmable pattern formation in cellular systems with local signaling
2021-06-17
journal article
Communications Physics
URL: http://dx.doi.org/10.1038/s42005-021-00639-8
DOI: 10.1038/s42005-021-00639-8
ISSN: 2399-3650
Determinants of the assembly and function of antibody variable domains
2017
journal article
Scientific reports
DOI: https://doi.org/10.1038/s41598-017-12519-9

See ORCID profile of Stephan Kremser as well.

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