This module handbook serves to describe contents, learning outcome, methods and examination type as well as linking to current dates for courses and module examination in the respective sections.
Module version of WS 2011/2
There are historic module descriptions of this module. A module description is valid until replaced by a newer one.
|available module versions|
|SS 2012||WS 2011/2|
WZ3213 is a year module in English language at Master’s level which is offered every semester.
This Module is included in the following catalogues within the study programs in physics.
- Catalogue of non-physics elective courses
|Total workload||Contact hours||Credits (ECTS)|
|150 h||60 h||5 CP|
Content, Learning Outcome and Preconditions
Tumor suppressor genes (definitions, Knudson two hit hypothesis, PTEN, Checkpoints of the cell cyc-le, pRB, p53, MDM2, Apoptose); Epigenetik (definitions, histone modifications, DNA methylation, pRb, CpG Islands, Examples, experiments of Mary Hendrix); Environment of the cell (components of a tu-mor, tumor stroma as therapeutical target, Extra cellular matrix: Components and meaning, interac-tions cell/ECM, Zell-Zell contact); Mechanisms of the metastasis cascade (steps of the cascade, Angi-ogenese, angiogenic switch, Invasion, cicatrization and cancer, tumor associated Mac-rophagen, epi-thelial mesenchymal transition, seed and soil hypothesis, role of proteases, metastatic niche; Marker-gene; Metastasis models in the mouse ); Proteases/proteolytic network (physiological and pathophysi-ological functions of proteases and protease inhibitors, regulation of proteases, splitting mechanisms, the proteolytic balance, Proteasenfamilien, Proteases as prognostic Marker, development of synthetic protease inhibitors, clinical examinations, optimization of synthetic protease inhibitors, the Cancerde-gradome); Specific methodology of the molecular oncology (in vivo model, biochemical/molecular proof methods of proteases and protease inhibitors, Zymography, knock-out Systeme, siRNA, shRNAi, viral vector systems, in vitro migration and invasion models); Deepening of the mentioned areas (discussion of current publications from relevant professional journals, acquirement of a recessed understanding of the learnt mechanisms)
Courses, Learning and Teaching Methods and Literature
Courses and Schedule
|VO||2||Molecular Oncology 1MED||Krüger, A.||
Tue, 17:15–18:45, 51.0.52
|SE||2||Molecular Oncology I Term Paper||Krüger, A.|
Learning and Teaching Methods
Study of the script and the notes taken, suggested follow-ups in the literature.
The Biology of Cancer. R. A. Weinberg. Garland Science, 1. Auflage, ISBN: 0-8153-4076-1