Molecular Cell Biology of Tumorigenesis
This module handbook serves to describe contents, learning outcome, methods and examination type as well as linking to current dates for courses and module examination in the respective sections.
Module version of WS 2019/20 (current)
There are historic module descriptions of this module. A module description is valid until replaced by a newer one.
Whether the module’s courses are offered during a specific semester is listed in the section Courses, Learning and Teaching Methods and Literature below.
|available module versions|
|WS 2019/20||WS 2011/2||SS 2011|
WZ2427 is a year module in German or English language at Master’s level which is offered every semester.
This Module is included in the following catalogues within the study programs in physics.
- Focus Area Bio-Sensors in M.Sc. Biomedical Engineering and Medical Physics
|Total workload||Contact hours||Credits (ECTS)|
|180 h||90 h||6 CP|
Content, Learning Outcome and Preconditions
- Tumor Viruses
- Oncogenes, tumor suppressor genes and tumor modulators
- Signal transduction and growth factors
- Cytoskeleton, cell adhesion and cell migration
- Cell cycle and cell division
- Telomer structure and chromosomal instability
- apoptosis and necrosis, as well as other forms of cell death
- Adult stem cells and "tumor stem cells", tumor metabolism
- Embryonic development of the mouse, embryonic stem cells, knock-out and knock-in technique
- Mouse models in biomedical research: Xenotransplant models, transgenesis in mice
- Tissue-specific and inducible models: Cre/LoxP, Crispr/Cas mutagenesis
- Imaging techniques in tumor research (multiphoton microscopy, MRT, PET/CT, OCT)
- Tumor-Stroma Interactions
- Basics of tumor immunology
- Basics of "rational therapy
They know how to move independently and confidently between clinical application and basic scientific knowledge in the field of biomedical cancer research. Students are able to independently evaluate current, English-language technical literature in the field of cancer research. Successful graduates have acquired a broad knowledge to analytically structure and experimentally solve problems in the field of cancer research, supported by practical research skills and experimental-analytical knowledge from the research internship.
Courses, Learning and Teaching Methods and Literature
Courses and Schedule
|VO||2||Molecular Cell Biology of Tumorigenesis (part 2)||
Responsible/Coordination: Janßen, K.
Learning and Teaching Methods
script (download possibility for lecture material on TUMonline) set to Moodle
2) Textbook of Molecular Cell Biology, Alberts et al., Wiley VCH, 2007 ISBN: 3527311602
3) The Mouse in biomedical research. James G. Fox (Ed.). Academic Press, 2007. ISBN: 9780123694546
4) Mouse Models of Human Cancer. Eric C. Holland (Editor), Wiley-VCH, 2004 ISBN: 978-0-471-44460-2
Description of exams and course work
A 20-minute presentation (graded, incl. written handout) is intended to demonstrate the acquisition of the competence to independently and critically interpret current research work from the English language literature. The presentation will be given as a mid-term performance (weighting: exam 66%, mid-term performance 33%) and will be taken into account in the examination period at the end of the second semester, but not on a repeat exam.
There is a possibility to take the exam in the following semester.