Physics of Genes 1: Nucleic Acids
This module handbook serves to describe contents, learning outcome, methods and examination type as well as linking to current dates for courses and module examination in the respective sections.
PH2277 is a semester module in German or English language at which is offered in winter semester.
This Module is included in the following catalogues within the study programs in physics.
- Specific catalogue of special courses for Biophysics
- Complementary catalogue of special courses for condensed matter physics
- Complementary catalogue of special courses for nuclear, particle, and astrophysics
- Complementary catalogue of special courses for Applied and Engineering Physics
If not stated otherwise for export to a non-physics program the student workload is given in the following table.
|Total workload||Contact hours||Credits (ECTS)|
|150 h||60 h||5 CP|
Responsible coordinator of the module PH2277 is Friedrich Simmel.
Content, Learning Outcome and Preconditions
in biotechnology, genetic engineering and nanotechnology 2. follow presentations dealing with biophysical properties of nucleic acids and participate in the corresponding scientific discussions. 3. independently educate themselves through literature research, based on the foundations laid in the lecture 4. carry out simple calculations on DNA structure and thermodynamics, also with the help of computer programs
No preconditions in addition to the requirements for the Master’s program in Physics.
Basic knowledge of biophysics and biochemistry is helpful.
Courses, Learning and Teaching Methods and Literature
Courses and Schedule
|VO||2||Physics of Genes 1: Nucleic Acids||Simmel, F.||
Thu, 10:00–12:00, ZNN 2.003
and singular or moved dates
|UE||2||Exercise to Physics of Genes 1: Nucleic Acids||
Responsible/Coordination: Simmel, F.
Learning and Teaching Methods
The students will be involved in scientific discussions and ecouraged to apply their knowledge to specific problems. In the exercises, the learning content is deepened and practiced by discussing specific problems of nucleic
acid biophysics and corresponding example calculations. Moreover, in the exercises special literature will be
read and discussed in detail.
Vologodskii, Biophysics of DNA, Cambridge University Press
Bloomfield, Crothers, Tinoco, Nucleic Acids, University Science Books
Bates & Maxwell, DNA Topology, Oxford University Press
Phillips, Kondev, Theriot, Garcia, Physical Biology of the Cell, Garland Science
Further specialist literature (publications) will be provided and discussed in the lecture and in the accompanying exercises
Description of exams and course work
There will be an oral exam of about 25 minutes duration. Therein the achievement of the competencies given in section learning outcome is tested exemplarily at least to the given cognition level using comprehension questions and sample calculations.
For example an assignment in the exam might be:
- Describe quantitatively the mechanical properties of single- and double-stranded DNA
- Which quantities are used to describe the topology of DNA molecules?
- Determine the secondary structure of a given (short) nucleic acid sequence
- How do you calculate the melting point of a given DNA sequence?
In the exam no learning aids are permitted.
The exam may be repeated at the end of the semester.