Chemistry in Biomedical Imaging for Physicists

1.     Introduction to biomedical imaging

2.     Introduction to the chemistry involved in the biomedical imaging modalities

3.     Chemical methodology for labelling and bioconjugation

4.     Contrast agents for computed tomography (CT)

5.     Nanoparticle-based contrast agents for CT

6.     Contrast agents for magnetic resonance imaging (MRI)

7.     Nanoparticle-based contrast agents for MRI

8.     Contrast agents for microscopy

9.     Organic molecules and proteins for microscopic imaging     techniques

10.  Immunofluorescence techniques

11.  Contrast agents for positron emission tomography (PET) I

12.  Contrast agents for PET II

13.  Multimodal imaging, emerging modalities and techniques

After successful lecture participationthestudent is able to:

• apply the basic principles of the discussed biomedical imaging techniques (computed tomography, microscopic techniques, magnetic resonance imaging and positron emission tomography) for assigning chemical properties to contrast agents used for biomedical imaging;
• identify the biomedical imaging technique(s) being addressed with a specific contrast agent;
• analyze chemical structures, properties and strategies regarding biomedical imaging in a clinical and research context.

Oral presentation

Quiz

Teamwork

Case study method

Discussions

Textbook/Scientific article

Power point presentation

Online quiz

Whiteboard

Textbook/Scientific article

Worksheet

1. N. J. LongandW.-T.Wong,Thechemistryofmolecularimaging.2015,Hoboken,New Jersey:Wiley.

2. H. Y. Chen,M. M.Rogalski,andJ. N.Anker,AdvancesinfunctionalX-rayimaging echniquesandcontrastagents.PhysicalChemistry

    ChemicalPhysics,2012.14(39):p.13469-13486.

3. H. Lusicetal.,X-raycomputedtomographycontrastagentsforcartilageimaging.Abstracts ofPapersoftheAmericanChemicalSociety,

    2012.244.

4. N. Lee,S. H.Choi,andT.Hyeon,Nano-SizedCTContrastAgents.AdvancedMaterials, 2013.25(19):p.2641-2660.

5. N. J. Pelc,RecentandFutureDirectionsinCTImaging.AnnalsofBiomedicalEngineering, 2014.42(2):p.260-268.

6. Y. L. Liu,K. L.Ai,andL. H.Lu,NanoparticulateX-rayComputedTomographyContrast Agents:FromDesignValidationtoinVivo

    Applications.AccountsofChemicalResearch,2012.45(10):p.1817-1827.

7.V. ShirshahiandM.Soltani,Solidsilicananoparticles:applicationsin

    molecular imaging.Contrast Media & Molecular Imaging, 2015.10(1):p.117.

8. S. I. Ziegler,Positronemissiontomography:Principles,technology,andrecent developments.NuclearPhysicsA,

    2005. 752:p.679C-687C.

9. M. BraddockandRoyalSocietyofChemistry(GreatBritain),Biomedicalimaging – The chemistryoflabels,probesand

    contrast agents,inRSCdrugdiscovery.2011,Royal SocietyofChemistry,:Cambridge.p.1onlineresource(1v.).

10. L. Helm,A. E.Merbach,andE.v.Tóth,Thechemistryofcontrastagentsinmedicalmagnetic resonanceimaging.Secondedition/ed.

      2013, Hoboken,NJ:JohnWiley&SonsInc.

11. D.  W.  Townsend,Multimodalityimagingofstructureandfunction.PhysicsinMedicineand Biology,2008.53(4):p.R1-R39.

There will be an oral exam of 25 minutes duration. Therein the achievement of the competencies given in section learning outcome is tested exemplarily at least to the given cognition level using comprehension questions and case studies.

For example an assignment in the exam might be:

• Why is gadolinium used in MRI contrast agent design?
• Review the chemical structures on the provided worksheet and assign each substance to the biomedical imaging technique(s).
• What contrast agent is the best choice? Discuss the question by using the provided table.