Chemistry in Biomedical Imaging for Physicists
Module version of WS 2017/8
There are historic module descriptions of this module. A module description is valid until replaced by a newer one.
Whether the module’s courses are offered during a specific semester is listed in the section Courses, Learning and Teaching Methods and Literature below.
|available module versions|
|WS 2020/1||SS 2020||WS 2019/20||SS 2019||SS 2018||WS 2017/8||WS 2015/6|
PH2226 is a semester module in English language at Master’s level which is offered in winter semester.
This Module is included in the following catalogues within the study programs in physics.
- Specific catalogue of special courses for Biophysics
- Specific catalogue of special courses for Applied and Engineering Physics
- Focus Area Imaging in M.Sc. Biomedical Engineering and Medical Physics
- Complementary catalogue of special courses for condensed matter physics
- Complementary catalogue of special courses for nuclear, particle, and astrophysics
If not stated otherwise for export to a non-physics program the student workload is given in the following table.
|Total workload||Contact hours||Credits (ECTS)|
|150 h||75 h||5 CP|
Responsible coordinator of the module PH2226 in the version of WS 2017/8 was Franz Pfeiffer.
Content, Learning Outcome and Preconditions
1. Introduction to biomedical imaging
2. Introduction to the chemistry involved in the biomedical imaging modalities
3. Chemical methodology for labelling and bioconjugation
4. Contrast agents for computed tomography (CT)
5. Nanoparticle-based contrast agents for CT
6. Contrast agents for magnetic resonance imaging (MRI)
7. Nanoparticle-based contrast agents for MRI
8. Contrast agents for microscopy
9. Organic molecules and proteins for microscopic imaging techniques
10. Immunofluorescence techniques
11. Contrast agents for positron emission tomography (PET) I
12. Contrast agents for PET II
13. Multimodal imaging, emerging modalities and techniques
After successful lecture participationthestudent is able to:
- apply the basic principles of the discussed biomedical imaging techniques (computed tomography, microscopic techniques, magnetic resonance imaging and positron emission tomography) for assigning chemical properties to contrast agents used for biomedical imaging;
- identify the biomedical imaging technique(s) being addressed with a specific contrast agent;
- analyze chemical structures, properties and strategies regarding biomedical imaging in a clinical and research context.
Courses, Learning and Teaching Methods and Literature
Courses and Schedule
|VO||2||Chemistry in Biomedical Imaging for Physicists||
Assistants: Busse, M.
Tue, 08:30–10:00, PH 2074
Learning and Teaching Methods
Case study method
Power point presentation
1. N. J. LongandW.-T.Wong,Thechemistryofmolecularimaging.2015,Hoboken,New Jersey:Wiley.
2. H. Y. Chen,M. M.Rogalski,andJ. N.Anker,AdvancesinfunctionalX-rayimaging echniquesandcontrastagents.PhysicalChemistry
3. H. Lusicetal.,X-raycomputedtomographycontrastagentsforcartilageimaging.Abstracts ofPapersoftheAmericanChemicalSociety,
4. N. Lee,S. H.Choi,andT.Hyeon,Nano-SizedCTContrastAgents.AdvancedMaterials, 2013.25(19):p.2641-2660.
5. N. J. Pelc,RecentandFutureDirectionsinCTImaging.AnnalsofBiomedicalEngineering, 2014.42(2):p.260-268.
6. Y. L. Liu,K. L.Ai,andL. H.Lu,NanoparticulateX-rayComputedTomographyContrast Agents:FromDesignValidationtoinVivo
molecular imaging.Contrast Media & Molecular Imaging, 2015.10(1):p.117.
8. S. I. Ziegler,Positronemissiontomography:Principles,technology,andrecent developments.NuclearPhysicsA,
9. M. BraddockandRoyalSocietyofChemistry(GreatBritain),Biomedicalimaging – The chemistryoflabels,probesand
contrast agents,inRSCdrugdiscovery.2011,Royal SocietyofChemistry,:Cambridge.p.1onlineresource(1v.).
10. L. Helm,A. E.Merbach,andE.v.Tóth,Thechemistryofcontrastagentsinmedicalmagnetic resonanceimaging.Secondedition/ed.
11. D. W. Townsend,Multimodalityimagingofstructureandfunction.PhysicsinMedicineand Biology,2008.53(4):p.R1-R39.
Description of exams and course work
There will be an oral exam of 25 minutes duration. Therein the achievement of the competencies given in section learning outcome is tested exemplarily at least to the given cognition level using comprehension questions and case studies.
For example an assignment in the exam might be:
- Why is gadolinium used in MRI contrast agent design?
- Review the chemical structures on the provided worksheet and assign each substance to the biomedical imaging technique(s).
- What contrast agent is the best choice? Discuss the question by using the provided table.
The exam may be repeated at the end of the semester.