Bioprinting: Fundamentals and Applications (Bioprinting: Fundamentals and Applications)
This module handbook serves to describe contents, learning outcome, methods and examination type as well as linking to current dates for courses and module examination in the respective sections.
MW2479 is a semester module in English language at Master’s level which is offered in summer semester.
This Module is included in the following catalogues within the study programs in physics.
- Focus Area Bio-Sensors in M.Sc. Biomedical Engineering and Medical Physics
|Total workload||Contact hours||Credits (ECTS)|
|150 h||45 h||5 CP|
Content, Learning Outcome and Preconditions
The module “Bioprinting” provides an overview of this multidisciplinary research area and the knowledge in bioprinting technologies, bioinks, 3D in vitro models and organoids. The course starts with an overview of the historical developments and the general motivation to manufacture biologically functional tissue. Next, established extrusion-, droplet- and laser-based bioprinting technologies as well as emerging approaches (e.g. microfluidic bioprinting, volumetric bioprinting) are discussed with respect to their advantages and disadvantages, and fields of application. The course highlights the printing parameters as well as methods to assess extrudability and shape fidelity. Fundamental basics in cell culture are introduced to understand the general biological requirements as well as design criteria for bioinks to encapsulate cells. To familiarize students with translational aspects, the course discusses the regulatory considerations for bioprinting processes and products. The course will explain technical as well as interdisciplinary competences, which are not only relevant to the field of bioprinting, but also relevant for biomedical engineering in general.
The following topics are covered in this module (subjected to change):
• Introduction to bioprinting: historical developments, motivation and applications
• Definition and comparison of state-of-the-art bioprinting technologies
• Introduction to basics cell culture and stem cells
• Classification and design criteria for bioinks
• Fundamentals and applications of crosslinking methods in bioprinting
• Methods to evaluate the extrudability, shape fidelity, and printing accuracy
• Methods to assess cell viability and proliferation
• In vitro 3D models of human tissue/organs and organoids: biofabrication and potential
• Translational applications and future challenges
• Regulatory considerations for processes and products
• understand the operating principles of bioprinting technologies
• evaluate the existing bioprinting technologies and their specific advantages and disadvantages
• demonstrate an understanding of the design criteria for bioinks and formulate bioink specifications for bioprinting technologies and application areas
• describe methods to assess cell viability and proliferation
• analyze current challenges in the field of biofabrication
• formulate regulatory consideration for processes and products
Courses, Learning and Teaching Methods and Literature
Courses and Schedule
|VO||2||Bioprinting||Eggert, S. Mela, P. Zhong, Z.||
|UE||1||Bioprinting: Exercise||Eggert, S. Mela, P. Zhong, Z.||
|TT||1||Bioprinting: Tutorial||Eggert, S. Mela, P. Zhong, Z.||
Learning and Teaching Methods
 Sun, W. et al. (2020). The Bioprinting Roadmap. Biofabrication, 12(2), 022002.
 Moroni, L., et al (2018). Biofabrication: a guide to technology and terminology. Trends in biotechnology, 36(4), 384-402.
 Groll, J., et al. (2016). Biofabrication: reappraising the definition of an evolving field. Biofabrication, 8(1), 013001.
 Bedell, M. et al. (2020). Polymeric systems for bioprinting. Chemical Reviews, 120(19), 10744-10792.
 Schwab, A. et al. (2020). Printability and shape fidelity of bioinks in 3D bioprinting. Chemical Reviews, 120(19), 11028-11055.
 Levato, R., et al. (2020). From shape to function: the next step in bioprinting. Advanced Materials, 32(12), 1906423.
Description of exams and course work
Resources for the exam: none (except writing materials)
There is a possibility to take the exam in the following semester.
Current exam dates
Currently TUMonline lists the following exam dates. In addition to the general information above please refer to the current information given during the course.
|Bioprinting: Fundamentals and Applications|
|Tue, 2022-02-22, 17:00 till 18:30||MW: 1450
||Melden Sie sich bitte nur an, wenn Sie die Präsenzprüfung verbindlich auch nach Lektüre der Informationen unter https://www.tum.de/die-tum/aktuelles/coronavirus/pruefungen ablegen werden. Informieren Sie sich vorab unter https://www.tum.de/die-tum/aktuelles/coronavirus/coronalehre-pruefungen/ über die Teilnahmevoraussetzungen. Personen, die einer Gruppe mit erhöhtem Risiko für einen schweren Verlauf angehören und an der Präsenzprüfung teilnehmen möchten, sind gehalten, die notwendigen Maßnahmen zum Eigenschutz zu treffen bzw. von der Teilnahme abzusehen. Hier kann der Krisenstab (email@example.com) oder der behandelnde Arzt beraten.||till 2022-01-15 (cancelation of registration till 2022-02-15)|