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BioMEMS and Microfluidics

Module EI7473

This Module is offered by TUM Department of Electrical and Computer Engineering.

This module handbook serves to describe contents, learning outcome, methods and examination type as well as linking to current dates for courses and module examination in the respective sections.

Basic Information

EI7473 is a semester module in German or English language at Master’s level which is offered every semester.

This Module is included in the following catalogues within the study programs in physics.

  • Focus Area Bio-Sensors in M.Sc. Biomedical Engineering and Medical Physics
  • Catalogue of non-physics elective courses
Total workloadContact hoursCredits (ECTS)
150 h 60 h 5 CP

Content, Learning Outcome and Preconditions

Content

We will cover basic concepts and applications of microfluidics and microelectromechanical systems (MEMS) for biological applications. The course will bring together different aspects of electrodynamics, surface science, and fluid mechanics that describe the operation principles of micro- or nanofabricated lab-on-a-chip systems in life science applications. We will start by introducing the general physical concepts followed by application examples. In the following, we will introduce cell-based microfluidic systems and functional biohybrids. In this context, we will highlight selected techniques and models for on-chip neuroscience applications.

Topics:
• Introduction to polymer-based microsystems & printing technologies
• Introduction to fluid mechanics: applications of the Navier-Stokes equation
• The diffuse structure of the electrical double layer
• Electroosmosis
• Electrophoresis
• Dielectrophoresis
• Magnetophoresis
• Electrowetting
• Droplet microfluidics
• Microfluidic cell culture systems: Network patterning & axon guiding
• Cell-chip communication & biohybrid systems
• On-chip neuroscience

Learning Outcome

After participation in this course, the student is able to:
1. compare different models for electrode/electrolyte interfaces and explain their limitations
2. illustrate the physical concepts and applications for on-chip particle and droplet actuation
3. understand the mechanisms of electrically and electrochemically coupled cell-chip interfaces
4. describe various methods of neuronal network patterning

Preconditions

Bachelor of Electrical Engineering, Physics, Chemistry, Biology or equivalent.

Courses, Learning and Teaching Methods and Literature

Courses and Schedule

Learning and Teaching Methods

The module will comprise lectures (2SWS) and exercises (2SWS). The lectures will introduce the students to the concepts of BioMEMS and microfluidics. During the exercise, the students will solve and discuss related problems. This will help the students to achieve a deeper understanding of the topics and learn to apply the taught concepts to practical tasks. In combination, this will help the students to acquire the teaching goals, which are listed above.

Media

no info

Literature

no info

Module Exam

Description of exams and course work

Written exam: 100% (2 hrs)
In order to individually monitor the learning progress, the students are given weekly problems related to the current lecture topics, which will be solved during the excercise (pass/fail exams).
In the written exam, the students demonstrate their knowledge of BioMEMS and associated physical phenomena by answering questions with limited supporting material. They will also show their ability to transfer the conveyed concepts by solving BioMEMS- and microfluidics-related problems.
To pass the module it is required that at least 50% of the pass/fail-exams are passed.

Exam Repetition

There is a possibility to take the exam in the following semester.

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