Flow Lithography (Flow Lithography (Lectures and Exercises))
This module handbook serves to describe contents, learning outcome, methods and examination type as well as linking to current dates for courses and module examination in the respective sections.
EI71097 is a semester module in English language at Master’s level which is offered every semester.
This Module is included in the following catalogues within the study programs in physics.
- Focus Area Bio-Sensors in M.Sc. Biomedical Engineering and Medical Physics
|Total workload||Contact hours||Credits (ECTS)|
|150 h||60 h||5 CP|
Content, Learning Outcome and Preconditions
1 Introduction to flow assisted lithography
2 Important physio-chemical concepts
2.1 Polymerization inside microfluidic channels
2.2 Single-phase flows in microfluidic channel
2.3 Microchannel material
2.4 Multi-phase flow in microfluidic channel
2.5 Particle-templated droplet formation
3 Categorization based on particle dimensions
3.1 1D, 1.5D, 2D, 2.5D, and 3D particles
4 Flow-assisted particle fabrication techniques
4.1 1D particles: droplet microfluidics lithography…
4.2 1.5D particles: non-spherical lithography…
4.3 2D particles: continuous flow lithography…
4.4 2.5D particles: hydrodynamic flow lithography…
4.5 3D particles: inertial flow lithography…
5 Applications of particles
5.1 Particle-templated droplet formation
5.2 Cell-laden hydrogels (tissue scaffolds)
5.3 Diagnostics assays
5.4 Cell culture on the particles (cell-carrier)
1. compare various continuous and stop flow lithography techniques for microparticle fabrication
2. describe fabricated particles based on the dimensional complexity from 1D to 3D
3. distinguish the fabrication techniques based on their ability to fabricate complex particles
4. understand the use of these customizable particles in various biomedical applications
Courses, Learning and Teaching Methods and Literature
Courses and Schedule
|VI||4||Flow Lithography||Destgeer, G. Sahin, M. Werner, H.||
Learning and Teaching Methods
1. Chu, L.-Y. & Wang, W. Microfluidics for Advanced Functional Polymeric Materials. Microfluidics for Advanced Functional Polymeric Materials (Wiley-VCH Verlag GmbH & Co. KGaA, 2017). doi:10.1002/9783527803637
Reference review articles:
2. Tian, Y. & Wang, L. Complex three-dimensional microparticles from microfluidic lithography. Electrophoresis 41, 1491–1502 (2020).
3. Li, W. et al. Microfluidic fabrication of microparticles for biomedical applications. Chemical Society Reviews 47, 5646–5683 (2018).
4. Choi, A. et al. Recent advances in engineering microparticles and their nascent utilization in biomedical delivery and diagnostic applications. Lab Chip 17, 591–613 (2017).
5. Zavada, S. R. et al. Radical-Mediated Enzymatic Polymerizations. Int. J. Mol. Sci. 17, (2016).
Additional literature in terms of peer reviewed articles will be shared.
Description of exams and course work
Duration of the exam: 90min
In the written exam, the students demonstrate their knowledge of the microfluidics-based lithography processes for particle fabrication and their use in various applications by answering short questions.
The exam may be repeated at the end of the semester. There is a possibility to take the exam in the following semester.