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Univ.-Prof. Dr. Jan Jakob Wilkens

Photo von Univ.-Prof. Dr. Jan Jakob Wilkens.
Phone
+49 89 4140 4504
Room
E-Mail
wilkens@tum.de
Links
Page in TUMonline
Group
Associate Professorship of Medical Radiation Physics (Prof. Wilkens)
Job Titles
  • Professorship on Medical Radiation Physics (TUM School of Medicine)
  • Professor associated with the Physics Department

Courses and Dates

Offered Bachelor’s or Master’s Theses Topics

Auswirkung von Puls- und Atembewegungen auf die Dosisverteilung der Mikrostrahltherapie

Background:
Microbeam radiation therapy (MRT) is a novel, still preclinical approach for cancer treatment that uses micrometer sized x-ray treatment fields. One of the major obstacles for a clinical application of MRT is the availability of appropriate radiation sources. Currently only large synchrotrons provide the necessary dose rates and radiation quality required for clinical treatments. In our team, we developed a system that generates microbeams for preclinical studies with a conventional x-ray tube. In order to analyze the MRT dose distribution with focus on the effect of pulse and breathing motion, we are currently seeking a motivated and curious master student.


Tasks:
- Design and fabrication of a phantom to analyze effects of motion on the physical dose distribution of microbeams
- Phantom measurement of the motion effects at our preclinical x-ray source
- Possible: Simulation of the motion effects with Monte Carlo (TOPAS)
- Ex-/In-vivo experiments at our preclinical treatment machine with an interdisciplinary team of physicists and biologists
- Possible: Development of in-vivo gating (e.g. ECG or breathing gating) including programming a user interface for our preclinical treatment machine


Profile:
- Genuine interest in medical physics
- Advantage: programming skills (e.g. Matlab, Python, or C++)
- Advantage: wet lab experience

Contact: stefan.bartzsch@tum.de

suitable as
  • Master’s Thesis Condensed Matter Physics
  • Master’s Thesis Nuclear, Particle, and Astrophysics
  • Master’s Thesis Biophysics
  • Master’s Thesis Applied and Engineering Physics
  • Master’s Thesis Biomedical Engineering and Medical Physics
Supervisor: Jan Jakob Wilkens
Optimierung von Dual Energy CT in der Kleintier-Computertomographie am MRI

Introduction:

Computed tomography is a three-dimensional imaging method in which X-rays can be used to calculate slices of an object. Dual Energy CT uses the energy dependence of X-rays: The respective object is measured with different X-ray spectra, and the images obtained are subsequently processed and reconstructed. With the help of different algorithms, Dual Energy CT can extract much more information from the image than conventional imaging (monoenergetic images, electron density, material images, ...). Dual Energy CT devices are in use in human medicine since a few years; in this work the method is used on a small animal irradiation device for mice. Our dual energy method uses a calibration using calibration cylinders and two different X-ray spectra.

 

Tasks:

The master thesis focuses on the optimization of X-ray spectra and calibration and its effect on the measurement. When choosing the X-ray spectra, many combinations are possible by using different voltages and filters. The optimal combinations should be found by using different criteria and verified with a phantom. The calibration cylinders should be examined and improved with regard to their geometry and material. It should also be considered whether different calibration phantoms are advantageous for different measurement objects. Furthermore, it should be checked how stable the calibration is depending on the position in the device and the time. In all optimizations, the focus is on ensuring that the subsequent measurement of the object provides the most accurate possible result.

 

Requirements:

You are interested in medical physics, especially in X-ray diagnostics/radiotherapy?

You like to work experimentally and can imagine working in a clean room?

You have basic experience with Python and enjoy programming?

Contact:

Manuela Duda

manuela.duda@tum.de

Medical Radiation Physics / Prof. Wilkens

Klinikum rechts der Isar (MRI)

suitable as
  • Master’s Thesis Condensed Matter Physics
  • Master’s Thesis Nuclear, Particle, and Astrophysics
  • Master’s Thesis Biophysics
  • Master’s Thesis Applied and Engineering Physics
  • Master’s Thesis Biomedical Engineering and Medical Physics
Supervisor: Jan Jakob Wilkens
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