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Dr. rer. nat. Fatemeh Mirzapourshafiyi

Photo von Fatemeh Mirzapourshafiyi M.Sc..
Phone
+49 89 289-12193
Room
CPA: EG.033
E-Mail
fatemeh.shafiyi@tum.de
Links
Page in TUMonline
Group
Theory of Biological Networks

Offered Bachelor’s or Master’s Theses Topics

In vitro and in silico assessment of the microvascular network under fluid flow
Blood vessels deliver oxygen and necessary nutrients to all tissues in the body. During embryonic development, formation of the first primitive vascular labyrinth though vasculogenesis is followed by vascular network expansion and maturation through angiogenesis. The latter comprises formation of new blood vessels out of pre-existing ones and the subsequent vascular remodeling in order to adapt the vascular network to the specific metabolic demands of the surrounding tissue. Onset of blood flow into the primary vascular network is known for having major impacts on vascular remodeling ensuring the network’s efficiency through structural normalization and hierarchy. Owing to the fact that vessel remodeling is often found impaired in pathological angiogenesis, many therapeutic methods have been developed to interfere with the vessel growth and normalization strictly affecting vascular morphology. However, the exact correlation between vessel morphological variations and alterations in blood flow dynamics has not been fully elucidated. Moreover, while many animal models have been developed to assess the effect of blood fluid flow on vascular morphology, translating their outcomes to human vascular system is often challenging. Employing the recent state-of-the-art microfluidic techniques for human organ-on-a-chip developments, one can grow perfusable human capillaries on polymeric chips for direct investigation of vascular structural development under flow through real time observations. Taking advantage of our in-house established human microvasculature on PDMS chip models, this project is aimed to assess the impact of fluid flow on the microvascular network architecture and vessel caliber. You will be working with 2D network image datasets analysing the microvascular structural remodeling in response to the fluid flow.
suitable as
  • Master’s Thesis Biomedical Engineering and Medical Physics
Supervisor: Karen Alim
Wie Adern wachsen und sich anpassen
Unser Adernetzwerk ist wichtig um Sauerstoff und andere wichtige Ressourcen in unserem Körper zu transportieren. Dabei ist unser Adernetzwerk nicht statisch sonder passt sich in seiner Struktur, in der Dicke einzelner Adern fortwährend an. Welche Gesetzmäßigkeiten folgt die Dynamik einzelner Adern? Welche Rolle spielt dabei die Strömung in den Adern? Du wirst Daten von Adernetzwerken auf einem Mikrofluidik Chip analysieren, um die Dynamik der Adern quantitativ zu erfassen. Dazu entwickelst Du Bildanalyseverfahren weiter und passt sich auf unsere ganz neuen Daten von Adern an. Neben der Bildanalyse bekommst Du auch Einblick in in vitro Techniken und Mikrofluidiktechniken.
suitable as
  • Bachelor’s Thesis Physics
Supervisor: Karen Alim

Publications

Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis
Fatemeh Mirzapour-Shafiyi (author), Daniel A. Beard (editor), Yukinori Kametani (author), Takao Hikita (author), Yosuke Hasegawa (author), Masanori Nakayama (author)
2021-06-16
journal article
PLOS Computational Biology
DOI: 10.1371/journal.pcbi.1008398
Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome
2020-12
journal article
Nature Communications
URL: http://dx.doi.org/10.1038/s41467-020-15198-9
DOI: 10.1038/s41467-020-15198-9
ISSN: 2041-1723
Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis
Fatemeh Mirzapour-shafiyi (author), Yukinori Kametani (author), Takao Hikita (author), Yosuke Hasegawa (author), Masanori Nakayama (author)
2020-10-13
other
DOI: 10.1101/2020.10.13.337295
aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability
2018-12
journal article
Nature Communications
URL: http://dx.doi.org/10.1038/s41467-018-07739-0
DOI: 10.1038/s41467-018-07739-0
ISSN: 2041-1723
PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow.
Hikita T (author), Mirzapourshafiyi F (author), Barbacena P (author), Riddell M (author), Pasha A (author), Li M (author), Kawamura T (author), Brandes RP (author), Hirose T (author), Ohno S (author), Gerhardt H (author), Matsuda M (author), Franco CA (author), Nakayama M (author)
2018-07
journal article
EMBO reports
URL: http://europepmc.org/abstract/med/30018153
PMID: 30018153
DOI: 10.15252/embr.201745253
VE-cadherin interacts with cell polarity protein Pals1 to regulate vascular lumen formation.
Brinkmann BF (author), Steinbacher T (author), Hartmann C (author), Kummer D (author), Pajonczyk D (author), Mirzapourshafiyi F (author), Nakayama M (author), Weide T (author), Gerke V (author), Ebnet K (author)
2016-07
journal article
Molecular biology of the cell
URL: http://europepmc.org/abstract/med/27466317
PMID: 27466317
PMC: PMC5025268
DOI: 10.1091/mbc.E16-02-0127

See ORCID profile of Fatemeh Mirzapourshafiyi as well.

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