Biomedizinische Physik

Prof. Franz Pfeiffer

Forschungsgebiet

Our interdisciplinary research portfolio is focused on the translation of modern x-ray physics concepts to biomedical sciences and clinical applications. We are particularly interested in advancing conceptually new approaches for biomedical x-ray imaging and therapy, and work on new kinds of x-ray sources, contrast modalities, and images processing algorithms. Our activities range from fundamental research using state-of-the-art, large-scale x-ray synchrotron and laser facilities to applied research and technology transfer projects aiming at the creation of improved biomedical device technology for clinical use. From a medical perspective, our work currently targets early cancer and osteoporosis diagnostics.

Adresse/Kontakt

James-Franck-Str. 1
85748 Garching b. München
+49 89 289 12552
Fax: +49 89 289 12548

Mitarbeiterinnen und Mitarbeiter der Arbeitsgruppe

Professorinnen und Professoren

Mitarbeiterinnen und Mitarbeiter

Lehrangebot der Arbeitsgruppe

Lehrveranstaltungen mit Beteiligung der Arbeitsgruppe

Titel und Modulzuordnung
ArtSWSDozent(en)Termine
Basic Mathematical Methods for Imaging and Visualization (IN2124)
Zuordnung zu Modulen:
VU 4 Lasser, T.
Mitwirkende: Göbl, R.Simson, W.Stefanoiu, A.
Di, 12:30–14:30, MW 1801
Mo, 16:00–18:00, 5620.01.102
Biomedizinische Physik 1
Zuordnung zu Modulen:
VO 2 Pfeiffer, F. Wilkens, J. Do, 12:00–14:00, PH HS2
Chemistry in Biomedical Imaging for Physicists
Zuordnung zu Modulen:
VO 2 Busse, M.
Leitung/Koordination: Pfeiffer, F.
Di, 14:00–16:00, PH 2074
Image Processing in Physics
Zuordnung zu Modulen:
VO 2 Achterhold, K. Mi, 10:00–12:00, MW 1050
Modern X-Ray Physics
Zuordnung zu Modulen:
VO 2 Achterhold, K. Di, 10:00–12:00, PH II 227
Biomedical Physics 1
Zuordnung zu Modulen:
HS 2 Pfeiffer, F.
Blockseminar zu aktuellen Themen in der Biomedizinischen Physik (E17 Seminarwoche)
Zuordnung zu Modulen:
HS 2 Herzen, J. Pfeiffer, F.
Modern X-Ray Physics
Zuordnung zu Modulen:
HS 2 Achterhold, K. Dierolf, M. Fr, 13:00–15:00, PH 2074
Seminar zu aktuellen Themen im BioEngineering (MSB-Seminar)
Zuordnung zu Modulen:
HS 2 Pfeiffer, F. Do, 13:00–14:00, IMETUM E.126
Exercises to Modern X-Ray Physics
Zuordnung zu Modulen:
UE 2 Günther, B.
Leitung/Koordination: Achterhold, K.
Exercise to Image Processing in Physics
Zuordnung zu Modulen:
UE 1 Hehn, L.
Leitung/Koordination: Achterhold, K.
Termine in Gruppen
Aktuelle Forschungsthemen in der Biomedizinischen Bildgebung (E17-Seminar)
Zuordnung zu Modulen:
SE 2 Herzen, J. Pfeiffer, F.
FOPRA-Versuch 79: Röntgencomputertomographie
Zuordnung zu Modulen:
PR 1 Pfeiffer, F.
Mitwirkende: Birnbacher, L.Viermetz, M.
Praktikum - Image Processing and Visualization using C++ (IN0012, IN2106, IN4186)
Diese Lehrveranstaltung ist keinem Modul zugeordnet.
PR 6 Lasser, T.
Mitwirkende: Stefanoiu, A.Virga, S.Weiss, J.

Ausgeschriebene Angebote für Abschlussarbeiten an der Arbeitsgruppe

Evaluierung der Variation des Röntgen-Dunkelfeld-Signals in einer vorklinischen Studie an Ex-Vivo Lungenproben

X-ray darkfield imaging has evolved as a novel x-ray imaging method, and offers great potential in the detection and visualisation of lung diseases (e.g. emohysema, fibrosis, lung cancer). In this project the variation of the darkfield signal variation shall be investigated in a small study with preclinical ex-vivo lung specimens. The work will be carried out in close collaboration with the Institute for Radiology and the Klinikum rechts der Isar.

geeignet als
  • Masterarbeit Physik der kondensierten Materie
  • Masterarbeit Kern-, Teilchen- und Astrophysik
  • Masterarbeit Biophysik
  • Masterarbeit Applied and Engineering Physics
Themensteller(in): Franz Pfeiffer
Fabrication of Grating-Structures for X-Ray Phase-Contrast Imaging using microstructured Si-Templates

X-ray phase-contrast radiography and computed tomography is a recently developed novel biomedical imaging method that allows for a better contrast in soft tissues. It has the potential to improve diagnosis of lung diseases and detection of tumor metastasis and is currently implemented in first clinical prototype systems. Presently, the required grating structures are made from Gold, which is too costly for large-area applications in the clinics. This master thesis focuses on the exploration of alternative materials to replace Gold as filling material.

geeignet als
  • Masterarbeit Physik der kondensierten Materie
  • Masterarbeit Kern-, Teilchen- und Astrophysik
  • Masterarbeit Biophysik
  • Masterarbeit Applied and Engineering Physics
Themensteller(in): Franz Pfeiffer
Spectral computed tomography for multi-material decomposition

Spectral computed tomography (CT) is an advancement of conventional CT. By using energy-resolving photon counting detectors, the technique offers several advantages compared to conventional CT. Besides a strong reduction in image noise and with that reduction of radiation dose, spectral CT enables an accurate determination of the chemical composition of an object. In the clinical routine this can be used to quantify the concentration of contrast agents in different organs in the human body. Making use of the K-edge discontinuities of different chemical elements allows for a clear separation between e.g. calcareous deposits and clinical contrast agents. However, spectral CT is not yet used for clinical diagnosis because the development of photon counting detectors with multiple energy bins which fulfill the clinical requirements is difficult.  The aim of the thesis is to evaluate the possibilities of multi-material decomposition with a novel prototype of a multi-bin photon-counting detector and to study the adaptability to different clinical cases. Furthermore new materials, such as gadolinium and tantalum, should be analyzed with respect to their potential usage as clinical contrast agents. The thesis  will be split between experimental activity in the laboratory (60 %) and data analysis, algorithmic implementation and computer simulations (40%).

 
geeignet als
  • Masterarbeit Physik der kondensierten Materie
  • Masterarbeit Kern-, Teilchen- und Astrophysik
  • Masterarbeit Biophysik
  • Masterarbeit Applied and Engineering Physics
Themensteller(in): Franz Pfeiffer

Abgeschlossene und laufende Abschlussarbeiten an der Arbeitsgruppe

Fabrication of Grating-Structures for X-Ray Phase-Contrast Imaging using microstructured Si-Templates
Abschlussarbeit im Masterstudiengang Physik (Physik der kondensierten Materie)
Themensteller(in): Franz Pfeiffer
Providing clinically relevant bone status information with scout views from a spectral CT scanner
Abschlussarbeit im Masterstudiengang Physics (Applied and Engineering Physics)
Themensteller(in): Franz Pfeiffer
LSTM for Parameter Inference in Sequential Models
Abschlussarbeit im Masterstudiengang Physics (Applied and Engineering Physics)
Themensteller(in): Marion Irene Menzel
Monte Carlo-based scatter correction for spectral computed tomography
Abschlussarbeit im Masterstudiengang Physics (Applied and Engineering Physics)
Themensteller(in): Franz Pfeiffer
Multimaterial Decomposition for Clinical Spectral CT
Abschlussarbeit im Masterstudiengang Physik (Physik der kondensierten Materie)
Themensteller(in): Franz Pfeiffer

Biophysik

Biologische Systeme, vom Protein bis hin zu lebenden Zellen und deren Verbänden, gehorchen physikalischen Prinzipien. Unser Forschungsbereich Biophysik ist deutschlandweit einer der größten Zusammenschlüsse in diesem Bereich.